Phosphatidic acid supplementation increases skeletal muscle hypertrophy and strength
نویسندگان
چکیده
منابع مشابه
Phosphatidic acid supplementation increases skeletal muscle hypertrophy and strength
Introduction The accretion of skeletal muscle tissue can be critical for a varied population including athletes and elderly. Skeletal muscle hypertrophy is largely mediated through increased muscle protein synthesis. The mammalian target of rapamycin (mTOR) has been shown to regulate rates of muscle protein synthesis and a mechanical stimulus (resistance exercise) has been shown to activate mTO...
متن کاملDiacylglycerol and Phosphatidic Acid in Rat Skeletal Muscle in Vivo
Contraction-induced translocation of protein kinase C (Richter E. A., Cleland, P. J. F., Rattigan, S., and Clark, M. G . (1987) FEBS Lett. 217,232-236) implies a role for this enzyme in muscle contraction or the associated metabolic adjustments. In the present study, this role is further examined particularly in relation to changes in glucose transport. Electrical stimulation of the sciatic ner...
متن کاملPhosphatidic acid feeding increases muscle protein synthesis and select mTORC1 pathway signaling mediators in rodent skeletal muscle
Background Human and cell culture studies have demonstrated that phosphatidic acid (PA) can increase muscle mass and anabolic signaling, respectively. However, no in vivo evidence to date has examined whether PA can increase intramuscular anabolic signaling in vivo. The purpose of this study was to examine – a) if PA feeding acutely increases post-prandial muscle protein synthesis (MPS) and ana...
متن کاملPhosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy
INTRODUCTION The lipid messenger phosphatidic acid (PA) plays a critical role in the stimulation of mTOR signaling. However, the mechanism by which PA stimulates mTOR is currently unknown. Therefore, the purpose of this study was to compare the effects of various PA precursors and phospholipids on their ability to stimulate mTOR signaling and its ability to augment resistance training-induced c...
متن کاملNew roles for Smad signaling and phosphatidic acid in the regulation of skeletal muscle mass
Skeletal muscle is essential for normal bodily function and the loss of skeletal muscle (i.e. muscle atrophy/wasting) can have a major impact on mobility, whole-body metabolism, disease resistance, and quality of life. Thus, there is a clear need for the development of therapies that can prevent the loss, or increase, of skeletal muscle mass. However, in order to develop such therapies, we will...
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ژورنال
عنوان ژورنال: Journal of the International Society of Sports Nutrition
سال: 2013
ISSN: 1550-2783
DOI: 10.1186/1550-2783-10-s1-p13